Would you like email updates of new search results? official website and that any information you provide is encrypted My labs would be either 9DPT or 8DPT. All my other transfers were 6 day embabies. With that in mind, here are examples of a normal doubling rate and a lower than normal doubling rate. Male factor infertility and ICSI are associated with relatively low HCG values in viable pregnancies. Try and relax enjoy being pregnant! Craciunas L, Tsampras N, Coomarasamy A, Raine-Fenning N. Cochrane Database Syst Rev. Good luck! Serum HCG has been found to be predictive of pregnancy outcome. Helping mothers, protecting Mother Earth. Hoping to go for another draw tomorrow at 19dpt! Copyright 2023 European Society of Human Reproduction and Embryology. Some women normally have a certain amount of hCG in the body naturally. To see a board-certified fertility specialist who will help you understand all your test results, make an appointment at one of InVia Fertility's four Chicago area fertility clinics. What does a high beta hCG mean? hCG level rises rapidly during the first trimester and then declines slightly. However, I believe that more goes into the assessment of HCG levels than just doubling, such as what time of the day the blood test is done. Next appt is in two weeks for an US. Beta HCG levels vary according to the gestational age. ;). We strive to provide you with a high quality community experience. This is in accordance with previous findings (Homan et al., 2000; Sugantha et al., 2000). (i.e., 700%). I appreciate the encouragement. Gold RS, Azem F, Yovel I, Wagman I, Amit A, Lessing JB. This educational content is not medical or diagnostic advice. Materials and Methods: All women underwent GnRH agonist suppression and controlled ovarian stimulation with gonadotropin administration. Hang in please; low beta rollercoaster is awful waiting for next test. In these pregnancies, the incidence of ectopic pregnancies (EP) varies from double to nearly 5-fold (Dubuisson et al., 1991; Strandell et al., 1999) compared with that in spontaneous pregnancies. The intra-assay variation was 2.7-5.1% and inter-assay variation 1.6-3.9% at the studied HCG levels. 3 While you should report any unusual bleeding to your doctor, spotting alone is not necessarily a good or bad sign. (, Ertzeid, G., Tanbo, T., Dale, P.O., Storeng, R., Morkid, L. and byholm, T. (, Frattarelli, J., Leondires, M., Miller, B. and Segars, J. HHS Vulnerability Disclosure, Help An abdominal ectopic pregnancy following a frozen-thawed ART cycle: a case report and review of the literature. Male factor infertility was associated with viable pregnancies (P = 0.004) and tubal factor with non-viable pregnancies (P = 0.003); the lowest HCG level (88 IU/l) was observed in subjects with both male factor infertility and ICSI treatment (P = 0.001). xx, Hi AmyK227 I don't have any direct experience on this, but everything I've read says that what counts is that HCG levels double every 48 hours or so. I just read your comments about tests being lighter than before, but I would still have hope. lower end of this range might indicate a problem with embryo implantation. 2/8 would be 1dp, correct. Optimal time interval between hysteroscopic polypectomy and frozen-thawed blastocyst transfer: A retrospective study. Results. METHODS: During 19941999, we studied 774 embryo transfer cycles resulting in pregnancy defined as a serum HCG concentration of 5 IU/l on day 12 following embryo transfer. The differences could be partly due to the different HCG assays used, and partly due to our decision, unlike the others, to regard the five late miscarriages (which have relatively high initial HCG) as non-viable pregnancies. A previous study (Gold et al., 2000), reported lower HCG concentrations 16 days after embryo transfer in ICSI compared with IVF in the subgroup of unexplained infertility. J Assist Reprod Genet. Day 4 and 5: Implantation continues and becomes complete. Before The rate of viable pregnancies was 71, 61, 53 and 48% in women aged up to 29, 3034, 3539 and 40 years respectively (P = 0.002). The spontaneous miscarriage rate was, therefore, 19.8% (22/111). 25 - 40 weeks LMP: 3,640 - 117,000 mIU/ml. We provide probabilities for each type of outcome for a given HCG level to help clinicians to counsel the patient and to plan the next step in her follow-up. Has anyone else had a similar level and went on to have a normal pregnancy? Find outstanding clinics from more than 400 fertility clinics in the USA. With a day 3 embryo transfer, it is best to wait at least 12-14 days before getting a pregnancy blood test. He has a special interest in health, lifestyle, & nutrition. You are right, need to just enjoy this! 7 10 weeks DPO: 25,700 288,000 mIU/ml, 11 14 weeks DPO: 13,300 254,000 mIU/ml, 15 22 weeks DPO: 4,060 165,400 mIU/ml, 23 38 weeks DPO: 3,640 117,000 mIU/ml, First test: Number of days since the transfer, and the beta hCG level on that day, Second test: Number of days since the transfer, and the beta hCG level on that day, Own eggs IVF (This option includes ICSI or no), Fresh donor egg IVF(This option includes ICSI or no), 3 Days frozen embryo transfer(This option calculate hCG levels after IVF 3 day transfer), 5 Days frozen embryo transfer(This option calculate hCG levels after IVF 5 day transfer). 1 7 7 comments Best Add a Comment [deleted] 2 yr. ago Notice this step is to examine, not judge. The hCG level has to rise appropriately (it doubles every 3 days or so in early pregnancy) till it reaches around 1500 mIU/mL. Please specify a reason for deleting this reply from the community. I tested positive on 5DPT. BACKGROUND: Assisted reproduction treatment (ART) entails a risk of ectopic pregnancy and early pregnancy loss. Thanks for checking in! What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Your gestational age and due date are calculated from when your egg began to mature (the start of your menstrual cycle), not from the time of conception. National Library of Medicine How soon you should check a pregnancy test after an embryo transfer. Congratulations! :) Best wishes to you! Progesterone levels are usually higher when you are pregnant, but even in a non-pregnant patient, they can reach 20 ng/ml. In natural frozen embryo transfer cycles, embryo transfer took place 3 days after the LH surge, as measured by using a home test kit. Lol. Our beta hCG calculator covers all IVF treatments, including HCG levels after IVF 3 days transfer, and 5 days transfer. The aetiology of infertility played some role in our study. My transfer was on 2/7 and I have my beta tomorrow. MeSH Please enable it to take advantage of the complete set of features! This site needs JavaScript to work properly. Clomid vs Letrozole: Which is Better for Infertility? There are no suggestions because the search field is empty. Since my transfer was at 12:30pm they said that 1DPT was not until Monday 2/8, not sure if this is right or not? F S Rep. 2020 Jun 30;1(1):48-50. doi: 10.1016/j.xfre.2020.04.005. Learn more about. It takes longer to start the implantation process and achieve a high enough hCG level to get a positive pregnancy test. hCG levels rise when an embryo implants in the uterus and a blood test can typically detect the hormone before at-home urine pregnancy tests. After egg retrieval, the specialist will attempt to fertilize the eggs. I had my transfer November 22nd with one frozen embryo. The most sensitive, accurate and reliable pregnancy test is a blood test for the presence of beta HCG , often just called "beta". My doctor said it was fine to start off low and that the doubling every two days is whats really important. The median HCG concentration in twin pregnancies was almost double that in singleton pregnancies (201 IU/l versus 115 IU/l, P < 0.0001). Please whitelist our site to get all the best deals and offers from our partners. One study broke out twin pregnancies and found that a beta HCG on day 13 after an embryo transfer of <207 mIU/mL had a 33% chance of delivering twins and a 55% risk of having a vanishing twin. Methods: Introduction Progesterone is an essential hormone involved in the process of implantation and pregnancy maintenance. Figure 2 shows the probabilities (%) of the different outcomes within each of the 10 deciles of the 774 day 12 post-embryo transfer HCG measurements. J Assist Reprod Genet. An ultrasound will confirm the location of pregnancy (normal or abnormal) and heartbeat of the baby can also be detected at this time. What's more important than the absolute beta number is if the number increases substantially over time. The presence of both factors together resulted in the lowest HCG concentrations among viable pregnancies. It is therefore important that you keep your follow-up monitoring visits and continue your medications until you are instructed not to do so by your physician. Our study did not include comparison with spontaneous pregnancies, but others have reported that early HCG in spontaneous pregnancies is higher than that in the IVF pregnancies (Tulchinsky et al., 1996; Ertzeid et al., 2000). Clinical pregnancy was defined as detection of an intrauterine gestational sac by TV-USG, and ongoing pregnancy was defined as a viable pregnancy detected by ultrasound examination at 16 . 2005-2023Everyday Health, Inc., a Ziff Davis company. Predictive value of hCG level 14 days after embryo transfer. But a blood test can detect it earlier. Just praying that things double on Thursday as they should. dont compare! My home pregnancy tests have been stronger every day but the digital one only said 1-2 weeks. I'm going in for a second beta on Wednesday but was wondering if anyone else had their first betas tested this early and what the HCG level was. (, Simberg, N., Tulppala, M., Husa, L.-M. and Tiitinen, A. hCG levels below 5 mIU/mL are considered negative for Just needs to double every 48hours. Does ICSI affect early serum beta-HCG in pregnancies achieved after IVF? A gestational sac and a yolk sac should be visible on ultrasound to be categorized as a clinical pregnancy. As stated above, the ultrasound findings are much more predictive of pregnancy outcomes than the hCG levels. 2575 centile range). It had increased from a 99 from the day before. In substituted frozen embryo transfer cycles, hormone replacement with estradiol valerate given orally (46 mg daily) was used until endometrial thickness reached 7 mm per two layers. Its been 11 days from my frozen embryo transfer. 3 embryos made it to blastocyst. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. For example, equal proportions of biochemical pregnancies, miscarriages, and viable pregnancies were observed at an HCG level of 3040 IU/l, which suggests that a second HCG reading a few days later would be helpful. Patients who had serum hCG concentrations higher than 5IU/l on D12 post embryo transfer were stratified and evaluated. Above 6,000 mIU/ml, the hCG often takes over four days to double. In many early IVF pregnancies, the hCG level will double every 48 to 72 hours. hCG levels also play a significant role after IVF. I am definitely feeling much more at ease after hearing these comments thank you. J Reprod Med. Clipboard, Search History, and several other advanced features are temporarily unavailable. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Report 0 Reply to Post. However, if your hCG level is falling, it is likely that the implantation was not successful. Records of the subjects who conceived following ART during that period were analysed. Male factor infertility was associated with viable pregnancy, probably reflecting normal female fertility combined with suboptimal male fertility. In simplest terms, the beta hCG test tells you how much hCG is in the blood. You have to use exact numbers, so you cant use basic hCG strips that you buy in a drugstore or pharmacy. My HCG was 34. A study of 177 IVF cycles showed that pregnancies with a beta hCG concentration<85 mIU/mL at Day 13 had an 89% risk of having a first trimester miscarriage, and pregnancies with -hCG >386mU/mL had a 91% chance of a live birth. The site is secure. Here are the options: And then, You can choose the egg retrieval date or embryo transfer date from the dropdown calendar or enter the start date by mm/dd/yyyy. Oh my gosh! On day 12 following embryo transfer, serum hCG level of each patient was determined by a fluoroimmunometric assay system. The earliest you can check a pregnancy test after a blastocyst transfer is 9-10 days. eCollection 2020 Jun. I started my first IVF cycle last month. hCG is not a hormone that your body usually produces. Male factor infertility was associated with viable pregnancies (P = 0.004) and tubal factor with non-viable pregnancies (P = 0.003); the lowest HCG level (88 IU/l) was observed in subjects with both male factor infertility and ICSI treatment (P = 0.001). Pregnancies were classified as viable (live fetus at > or =22 weeks gestation) or non-viable (biochemical pregnancy, miscarriage, ectopic pregnancy and molar pregnancy). Our study with 774 cycles is thus the largest of its kind. So, if your first beta is low, do not panic! Probabilities of each type of outcome related to the HCG level are given. The intra-assay variation was 2.75.1% and inter-assay variation 1.63.9% at the studied HCG levels. But what's more important than the absolute beta number that helps determine normal levels is the rate of increase over time (it should double every 48 hours). Always consult your physician in the area for your particular needs and circumstances prior to making any decisions whatsoever. We strive to provide you with a high quality community experience. Day 10: By the 10th to 12th day of development, the blastocyst is fully implanted. All content and information on this website are for informational and educational purposes only. Our aim was to assess the clinical value of a single early HCG assay in ART pregnancies taking into account the aetiology and treatment of infertility. Another study even showed that there is a lower rate of early miscarriage in the OHSS group (7.8%) than overall (16%). Here is a chart of outcomes based on beta hCG levels: IVF Transfer Outcome by Beta hCG Level on Day 14. Bethesda, MD 20894, Web Policies Probability (%) of each pregnancy outcome within each of the 10 centiles of serum HCG concentration at 12 days post embryo transfer. Caution must be used in making too much of hCG numbers. Please specify a reason for deleting this reply from the community. Analyses involving non-viable pregnancies were therefore carried out by the non-parametric MannWhitney U-test or Kruskal-Wallis analysis of variance. The 774 measurements available of day 12 HCG were divided in 10 deciles, each containing 77 or 78 cases, and the proportions of each outcome type within each decile were calculated. Get your query answered 24*7 only on | Practo Consult . The above hCG levelsare only a guide. (blastocyst) I am having period type pains, pelvic pain f . In most labs, a value greater than 5mlU/ml is considered positive. We are cautiously optimistic if there is a level under 50 on the first test. However, the HCG values in non-viable pregnancies remained non-normally distributed even after logarithmic or exponential transformations. However, the ultimate goal is a live birth, which is when you give birth to a healthy child. Hernandez-Nieto C, Lee J, Alkon-Meadows T, Briton-Jones C, Sandler B, Copperman A, Mukherjee T. J Assist Reprod Genet. True true. Evidence from recent studies has supported the importance of serum progesterone level around the time of embryo transfer in hormonal replacement therapy frozen embryo transfer cycles and recommended the need for individualised luteal support. I had ectopic on Feb 2014 . Day of transfer is 0dp. So my second beta was 126 at 10dp5dt. Of these, 774 embryo transfer cycles fulfilled our inclusion criteria, which were (i) serum HCG had been assayed on day 12 post embryo transfer and its concentration was 5 IU/l, (ii) the data on the outcome was available, and (iii) there were no known chromosomal anomalies or signs of `vanishing twin' syndrome in subsequent ultrasonography. Yanaihara A, Ohgi S, Motomura K, Hagiwara Y, Mogami T, Saito K, Yanaihara T. BMC Pregnancy Childbirth. I'm just too scared to be excited about the positive beta/pregnancy. 2010 Apr;20(4):504-9. doi: 10.1016/j.rbmo.2010.01.005. PMID: 30848135. Reply. 85% of normal pregnancies will have the HCG level double every 72 hours. Find advice, support and good company (and some stuff just for fun). The rate decreased from 20% within the 1st decile (HCG 514 IU/l) to 10% within the 2nd4th deciles (HCG 1566 IU/l) and to 0.8% for HCG values of 67 IU/l. Our time point for HCG sampling was the earliest suggested as being useful (Legro et al., 1995; Qasim et al., 1996; Bjercke et al., 1999). A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Reprod Biomed Online. Save my name, email, and website in this browser for the next time I comment. At this point, if the embryo has implanted, you will also get a positive urine pregnancy test. The number of women was 650. Within the uppermost decile (median 263, range 221683 IU/l), normal singleton pregnancy and twin pregnancy showed similar probabilities of 50%. Wish Id have waited till 14 days as recommended as Im eggs but only had 4 retrieved and two didnt make it so I have no more eggs. You should not rely solely on this information. Typically the hormone levels start low and ultimately downtrend back to negative. Has anyone else had a similar level and went on to have a normal pregnancy? PMC I think they are trained to say that kind of thing. You may experience light spotting after egg retrieval, after embryo transfer, or later in your luteal phase. Make An Appointment With Dr. Robles To Discuss Your Fertility Options Today! A low HCG concentration alone is therefore not a suitable marker for EP. In contrast, tubal factor infertility was associated with non-viable pregnancies, at least partly due to the increased incidence of EP (6% with tubal factor infertility compared with 0.8% without). An early loss in the paper is defined as a miscarriage before 6 weeks (so a miscarriage by 23DP5DT). You have no idea how much you just put me at ease. Second, and the main reason, is that specialists are looking for an increase in hCG, not merely the presence of it. To conduct an analysis that determines the level of hCG in the blood, it is advisable not earlier than two weeks after embryo transfer. Can biochemical pregnancy be determined 5 days after frozen-thawed embryo transfer? Low progesterone around the time of . I heard hcg doubles every 48 hours, does this apply to whatever baseline we have? The EP represented 59% at HCG ranges up to 80 IU/l, and only one subject with EP had a level higher than this (144 IU/l). Avoid checking an over the counter pregnancy test, as testing too early can result in a false negative. It is called the pregnancy hormone because it is only present during pregnancy and can be detected by early pregnancy tests or a blood test. Read More. When two or more follicles reached a diameter of >17 mm (in TVS), 10 000 IU of HCG was administered. Today I am 8dp5dt and had my beta done. Thus, a history of tubal infertility together with a low HCG calls for a second HCG and early localization of the pregnancy by transvaginal ultrasonography. There is no single hCG level or cut-off that defines a normal pregnancy. As soon as fertilization begins, the embryos begin aging. doi: 10.1371/journal.pone.0240882. Xx, Hi AmyK. Trying to stay positive and believing for a viable pregnancy. If the level was between 300 and 600, the ongoing . Days after implantation relative to hCG values are estimated and not part of the study.) its so hard to hear my RE say I am not hopeful, it does not give me all the feels I have my second draw tomorrow. The normal hCG levels for twins is 30% to 50% higher than in single pregnancy- somewhere around 200 to 1750 mIU/ml. Neither odds of implantation nor clinical pregnancy were influenced by maternal age, BMI or blastocyst expansion grade. Your number quadrupled. The study showed that twin pregnancies with a beta hCG 768 mIU/mL had an 81% chance of delivering live twins and a 19% risk of having a vanishing twin (there were no pregnancy losses in this group). Early -hCG levels predict live birth after single embryo transfer. Patients with ectopic pregnancies were also associated with low hCG values with the median concentration of 42.56 IU/l. I had my transfer November 22nd with one frozen embryo. My beta was 115 at 10dp5dt and now I am 18 weeks pregnant with twins. Serum HCG has been found to be predictive of pregnancy outcome. In a non-pregnant woman, they are less than 10 mIU/ml. The treatment included IVF in 518, ICSI in 119, and frozen embryo transfer in 137 cycles. I now keep saying slow and steady wins the race! Today I am 8dp5dt and had my beta done. Most HPTs will pick up an HCG reading 11 or 12 days after the embryo enters the uterus. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Is this too low?? Male factor infertility was present in 45 of 72 (63%) ICSI cycles; the other aetiological factors were anovulation in one, combined in 13, endometriosis in three, tubal factor in two and unexplained in eight ICSI cycles. I feel so heartbroken and empty. Use of this site is subject to our terms of use and privacy policy. What It's Like to Find Out You're Pregnant Through IVF. Urine tests. The approximately doubled HCG level in twin pregnancies is in accordance with the results of previous studies (Schimdt et al., 1994; Glatstein et al., 1995; Bjercke et al., 1999). My home pregnancy tests have been stronger every day but the digital one only said 1-2 weeks. The treatment included IVF in 518, ICSI in 119, and frozen embryo transfer in 137 cycles. In a pregnancy cycle, they should be greater than 10 to 12 ng/ml to have a better chance of a good pregnancy outcome. Human chorionic gonadotropin (hCG) is a hormone that is released by the human embryo after conception. Thanks so much. The frozen embryo is thawed before the transfer . If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. With that in mind, heres what you can expect to see: Keep in mind that the point of an hCG test is to determine if hCG levels are rising at a rate thats consistent with pregnancy. retrieve the eggs after they become mature but before they ovulate, Embryo Transfer Precautions: What You Should & Shouldnt Do, Miscarriage Symptoms After IVF (How To Know If Its Happening), Ectopic Pregnancy After IVF: Symptoms, Concerns, & Safety. It is important to remember that a blood pregnancy test is the earliest indicator of success for an in vitro fertilization cycle. Curious what individuals HCG levels were for a 5 day embryo transfer? 2022 Jan 17;26(1):62-67. doi: 10.5935/1518-0557.20210054. You will then receive an email that contains a secure link for resetting your password, If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password, DOI: https://doi.org/10.1016/S0015-0282(03)01359-1, Reproductive Science Ctr, Boston, MA, USA. The https:// ensures that you are connecting to the Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. 2020 Oct 20;15(10):e0240882. For my case, I should have more 8000 after two days? Yes, it is possible that you're carrying twins, but you should wait until your first ultrasound scant to confirm if it's a singleton or a multiple pregnancy. Supplements to Take During Fertility Treatments and IVF, The IVF Funnel: Understanding Your Chances of Success, 10% off your first month when you subscribe with code LUCKY23, Ovulation support program with a licensed healthcare provider. Dr. Karande is Board Certified in the specialty of Obstetrics and Gynecology as well as the subspecialty of Reproductive Endocrinology and Infertility. Enter the second hCG test date and beta hCG level, Step 4: Calculate and examine the results, Example Results from an IVF hCG Calculator, IVF Comparison Tool: Compare Fertility Clinics Success Rates, Fertility Clinic Rankings in the United States, IVF Cost Calculator: Costs of Own eggs, Donor, Surrogate, FET, ICSI and PGD, IVF due date calculator with one baby,twins or triplets, including 3 day and 5 day, IVF Success Rate Calculator Predict the Likelihood of Live Birth After IVF, Own eggs, Fresh donor eggs, Fresh donor embryos, consider the egg retrieval date as 0 day of DPO date, 14 days later after the egg retrieval date, consider embryo transfer date as 3 days of DPO date, 11 days later after the embryo transfer date, consider embryo transfer date as 5 days of DPO date, 9 days later after the embryo transfer date, Tell you the difference in levels from the first and second test, as a percentage (i.e., +525/+700% or -25/-67%), Give you a 2-day increase rate, regardless of how many days passed between your tests. In general, you should see your b hCG levels rising by ~50% every 48 hours. Zhang Q, Yan J, Tang R, Gao X, Zhang B, Chen ZJ. The previous studies on ART cycles relating early HCG determination with pregnancy outcome consisted of 77662 cycles and have been reviewed (Sugantha et al., 2000). Thanks! IQ range = interquartile range (i.e. IVF is successful when you have a healthy, viable pregnancy after the embryo transfer. Very low. It is used to diagnose pregnancy and a result greater than 5 mIU/mL is generally considered positive. So you will also choose or enter the second test date. The two cases of hydatidiform mole are not depicted. pregnant. Progesterone levels rise much differently than hCG levels, with an average of 1-3mg/ml every couple days until they reach their peak for that trimester. Human chorionic gonadotropin (hCG) is a hormone that is released by the human embryo after conception. Some fertility clinics check that the medication worked by checking your hCG hormones the next day after the trigger shot. But you should not have to worry about determining the stage of the embryos at transfer. FOIA It A low hCG level could mean the embryo has a slower implantation process. Thus our results are equally applicable to double and single embryo transfers. Zboilov B, Bezinov J, Tkadlec E, Prochzka M, Oborn I, Sobek A Jr, Sobek A. HCG level after embryo transfer as a prognostic indicator of pregnancy finished with delivery. My clinic has me on HCG boosters so I know this will show a slight positive so they asked me to repeat my levels in 2 days to be sure. . Below are the average hCG levels during the first trimester: 3 weeks LMP: 5 - 50 mIU/ml 4 weeks LMP: 5 - 426 mIU/ml 5 weeks LMP: 18 - 7,340 mIU/ml The study by Stone et al., showed that the doubling times of serum -hCG (-t2) increased from 1.6 days on day 12, to a doubling time 3 days on day 24 after embryo transfer [ 11 ], suggesting that -hCG doubled more quickly in early pregnancy. Shipping is not available outside of the United States. Embryo transfer was carried out 2 days after retrieval and the first pregnancy test was scheduled 12 days later (14 days after retrieval). When serum -hCG levels 12 days after transfer were evaluated according to the transfer day, the values that were most reliable in predicting clinical pregnancy were 57 mIU/mL for day 3 transfer cycles (sensitivity 71.2%, specificity 64.7%, CI: 0.59-0.79) (Figure 3), and 87 mIU/mL for day 5 transfers (sensitivity 71.2% (, Strandell, A., Thorburn, J. and Hamberger, L. (, Sugantha, S., Webster, S., Sundar, E. and Lenton, E. (, Tiitinen, A., Halttunen, M., Hrkki, P., Vuoristo, P. and Hyden-Granskog, C. (, Tulchinsky, D., Tulchinsky, A., Paoletti-Falcone, V., Nash, H., Pazdziorko, S. and Brown, K. (, Oxford University Press is a department of the University of Oxford.